View source for Publication/guo 2023 miniscopelfov

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{{Publication
|description=Miniscope-LFOV: A large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals
|document_type=Publication
|document_date=2023
|publication_status=Published
|publication_year=2023
|publication_type=Journal Article
|doi=10.1126/sciadv.adg3918
|journal=Science Advances
|volume=9
|issue=16
|pages=eadg3918
|abstract=Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger than mice remains a key endeavor of neuroscience. We present a large-field-of-view open-source miniature microscope (MiniLFOV) designed for large-scale (3.6 mm&nbsp;×&nbsp;2.7 mm), cellular resolution neural imaging in freely behaving rats. It has an electrically adjustable working distance of up to 3.5 mm&nbsp;±&nbsp;100 μm, incorporates an absolute head orientation sensor, and weighs only 13.9 g.&nbsp;The MiniLFOV is capable of both deep brain and cortical imaging and has been validated in freely behaving rats by simultaneously imaging &gt;1000 GCaMP7s-expressing neurons in the hippocampal CA1 layer and in head-fixed mice by simultaneously imaging ~2000 neurons in the dorsal cortex through a cranial window. The MiniLFOV also supports optional wire-free operation using a novel, wire-free data acquisition expansion board. We expect that this new open-source implementation of the UCLA Miniscope platform will enable researchers to address novel hypotheses concerning brain function in freely behaving animals. A large field of view open-source miniature microscope is capable of imaging large populations of neurons in rats and mice.
|website=https://www.science.org/doi/abs/10.1126/sciadv.adg3918
}}

{{Subobject/Has publication author
|last_name=Guo
|first_name=Changliang
|is_first_author=Yes
}}

{{Subobject/Has publication author
|last_name=Blair
|first_name=Garrett
|middle_name=J.
}}

{{Subobject/Has publication author
|last_name=Sehgal
|first_name=Megha
}}

{{Subobject/Has publication author
|last_name=Jimka
|first_name=Federico
|middle_name=N. Sangiuliano
}}

{{Subobject/Has publication author
|last_name=Bellafard
|first_name=Arash
}}

{{Subobject/Has publication author
|last_name=Silva
|first_name=Alcino
|middle_name=J.
}}

{{Subobject/Has publication author
|last_name=Golshani
|first_name=Peyman
}}

{{Subobject/Has publication author
|last_name=Basso
|first_name=Michele
|middle_name=A.
}}

{{Subobject/Has publication author
|last_name=Blair
|first_name=Hugh
|middle_name=Tad
}}

{{Subobject/Has publication author
|last_name=Aharoni
|first_name=Daniel
}}
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