https://miniscope.org/index.php?action=history&feed=atom&title=Publication%2Fguo_2023_miniscopelfov 2026-04-28T06:28:32Z Revision history for this page on the wiki MediaWiki 1.44.5 https://miniscope.org/index.php?title=Publication/guo_2023_miniscopelfov&diff=517&oldid=prev 2026-04-08T07:40:25Z

<p>citations-sync: update from BibTeX</p> <p><b>New page</b></p><div>&lt;!-- citations-sync start --&gt;<br /> {{Publication<br /> |description=Miniscope-LFOV: A large-field-of-view, single-cell-resolution, miniature microscope for wired and wire-free imaging of neural dynamics in freely behaving animals<br /> |document_type=Publication<br /> |document_date=2023<br /> |publication_status=Published<br /> |publication_year=2023<br /> |publication_type=Journal Article<br /> |doi=10.1126/sciadv.adg3918<br /> |journal=Science Advances<br /> |volume=9<br /> |issue=16<br /> |pages=eadg3918<br /> |abstract=Imaging large-population, single-cell fluorescent dynamics in freely behaving animals larger than mice remains a key endeavor of neuroscience. We present a large-field-of-view open-source miniature microscope (MiniLFOV) designed for large-scale (3.6 mm&amp;nbsp;×&amp;nbsp;2.7 mm), cellular resolution neural imaging in freely behaving rats. It has an electrically adjustable working distance of up to 3.5 mm&amp;nbsp;±&amp;nbsp;100 μm, incorporates an absolute head orientation sensor, and weighs only 13.9 g.&amp;nbsp;The MiniLFOV is capable of both deep brain and cortical imaging and has been validated in freely behaving rats by simultaneously imaging &amp;gt;1000 GCaMP7s-expressing neurons in the hippocampal CA1 layer and in head-fixed mice by simultaneously imaging ~2000 neurons in the dorsal cortex through a cranial window. The MiniLFOV also supports optional wire-free operation using a novel, wire-free data acquisition expansion board. We expect that this new open-source implementation of the UCLA Miniscope platform will enable researchers to address novel hypotheses concerning brain function in freely behaving animals. A large field of view open-source miniature microscope is capable of imaging large populations of neurons in rats and mice.<br /> |website=https://www.science.org/doi/abs/10.1126/sciadv.adg3918<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Guo<br /> |first_name=Changliang<br /> |is_first_author=Yes<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Blair<br /> |first_name=Garrett<br /> |middle_name=J.<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Sehgal<br /> |first_name=Megha<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Jimka<br /> |first_name=Federico<br /> |middle_name=N. Sangiuliano<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Bellafard<br /> |first_name=Arash<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Silva<br /> |first_name=Alcino<br /> |middle_name=J.<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Golshani<br /> |first_name=Peyman<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Basso<br /> |first_name=Michele<br /> |middle_name=A.<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Blair<br /> |first_name=Hugh<br /> |middle_name=Tad<br /> }}<br /> <br /> {{Subobject/Has publication author<br /> |last_name=Aharoni<br /> |first_name=Daniel<br /> }}<br /> &lt;!-- citations-sync end --&gt;<br /> [[Category:Publication]]</div>

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